Mammalian Membrane Two-Hybrid (MaMTH) Technology: a Novel Protein Interaction and Drug Discovery Tool

Complex multi-protein clusters play vital roles in many aspects of biology. Deregulation of these clusters may lead to several human diseases including cancer, cystic fibrosis, cardiovascular and neurodegenerative disorders. This technology uses a bait (protein of interest) - prey (candidate molecules) system to detect and identify novel interacting partners in a mammalian genetic system. Dr Stagljar has built upon his initial patented Membrane Yeast Two-Hybrid (MYTH) invention to propose a unique platform to discover new target molecules for research and drug development purposes. This technology provides a new tool to examine membrane proteins in their natural environment of the human cell. It is sensitive enough to detect minor changes upon the introduction of drugs and thus should prove useful in the development of therapeutics, especially for cancer and neurological diseases.

Start-up: Protein Network Sciences Inc.




Cancer , Cell Signaling , Disease Detection , Drug Discovery , Genetics , Membrane Proteins , Neurological Disorders , Protein-Protein Interactions , Proteins